Cells Derived from Adipose Tissue
In the early 2000s, Zhu et al. He found that in adipose tissue we have Mesenchymal Cells and other regenerative cells that have been shown to be effective in healing various ailments such as tendon, muscle lesions, acute Myocardial infarctions, chronic heart ischemia, fistulas, breast reconstruction, treatment of symptoms of Parry Romberg syndrome and others.
Therefore, in 2013, Dr. Cugat’s team began to study the use of stem cells derived from adipose tissue.
Focusing on its application to improve healing of anterior knee cruciate ligament surgeries and meniscal injury surgeries, with the intention not only that the patient can recover sooner, but also for the purpose of obtaining better healing. In this way, to reduce the possible degeneration associated with both meniscus and cartilage, and thus prevent the onset of osteoarthritis and the need to use prosthetics in the future.
As for the mechanisms of action of stem cells derived from adipose tissue, we know from the experiments made that the cells stay at the site of the injury and do not migrate to other organs, a mechanism known as “Home to Injury”. Studies have also shown its ability to reduce apoptosis (programmed cell death) of adjacent tissue cells. They modulate inflammation and increase vascularity through the segregation of growth factors by responding at all times to the context in which they are found. All this, makes the scarring of the lesion improve and can regenerate the injured and treated tissue