• Study the use of mesenchymal cells obtained from adipose tissue and growth-rich plasma in the canine species to repair cartilage in patients with osteoarthrosis

• This pathology, which affects a high number of people, is the leading cause of functional incapacity for work

• Osteoarthrosis also affects animals, being the leading cause of limping in the canine species in animals older than one year

The CEU Cardenal Herrera University, together with the García Cugat Foundation, carry out a pioneering project in the research of the treatment of joint degenerative disease or osteoarthrosis, through the use of mesenchymal cells obtained from adipose tissue and plasma rich in growth factors in the canine species. Today, joint degenerative disease is a very common pathology, affecting a large number of people, being the first cause of functional labour disability. The results obtained today in the project of the CEU-UCH and the García Cugat Foundation allow to consider this type of regenerative therapies as a new treatment route to achieve a repair as close to the native cartilage of patients, without the need to resort to more aggressive techniques and that cause greater damage to the organism.

New regenerative therapies

The new regenerative therapies, both with mesenchymal cells and with plasma rich in growth factors, allow to overcome the regenerative difficulty of cartilage, maintaining or improving the structure and joint function. The principle of this treatment is based on the ability of mesenchymal cells obtained from adipose tissue to differentiate into various cell types, thus being able to repair and supplement physiological functions in the affected joint. Proteins known as growth factors can optimize the outcome, facilitating the differentiation of these types of cells and thus improving therapy.

So far there is no treatment that completely solves osteoarthrosis, so the goal of current therapies is solely to reduce pain and discomfort, decrease clinical signs, slow the progression of the disease and promote the repair of injured tissue, thus improving the quality of life of the patient. Therefore, osteoarthrosis leads to a very high consumption of economic resources of the health system, both in the public and private sectors. In addition, like many other pathologies, this disease also affects animals, and in the case of the canine species is the leading cause of limping in animals older than one year.

In osteoarthrosis there is a progressive and irreversible process of joint cartilage degeneration, which causes inflammation and pain in the affected joint. These processes cause a decrease in the activity of the area, resulting in a significant deterioration of the musculature surrounding the joint. As a result, the diseased area begins to atrophy, making it increasingly complicated to use. Therefore, this new type of therapies represent an innovative and hopeful way for the treatment of joint degenerative disease.

Participating researchers

The professors of the Faculty of Veterinary Medicine of the Unviersidad CEU Cardenal Herrera de Valencia, José María Carrillo and Mónica Rubio, members of the Institute of Biomedical Sciences of this University, lead this research in collaboration with the García Cugat Foundation. This institution, created on 25 January 2007 by a group of doctors, veterinarians and researchers from Barcelona and Valencia, works on various projects within the field of biomedical research. It is named after García Cugat in homage to the orthopedic surgeon, traumatologist and specialist in physical education medicine José García Cugat, founder of the Spanish Association of Artroscopy.

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Source: The Press